Does the bias have a direction? Nc plot can indicate if there's a bias, but not which way it goes (eg. whether codon usage is more similar to host). We need another kind of analysis. Correlation of individual codon usage tables between two species: simplistic and not very powerful, but it can show us direction of codon bias. Obtain correlation coefficients based on frequency /1000 of individual codons for two species, get r value. no correlation 0 <- r -> 1 perfect correspondance